I really enjoy the “Save All” function in Visual Studio (2005). With a simple Ctrl+Shift+S, you save all open documents. The same functionality exists in Adobe Dreamweaver, but you must use the file menu to access it. I am a keyboard shortcut freak. I like quick execution of certain functions. Luckily, there is a way to create custom keyboard shortcuts in Adobe Dreamweaver CS3 (Mac version). 

1. Go to Dreamweaver > Keyboard Shortcuts …
    
2. In the Commands Window, go to File > Save All
3. Click into the Press key section
4. Use your keyboard combination
   Dreamweaver has a real nice validation system that will inform you if you are overriding any other command. 
   
5. The default sets can not be adjusted, so you will be prompted to create a new one. Select [OK]
   
6. Enter the name of the new set
7. Select [OK]

Voila!